Starting Zilxi


If you’ve already talked to your doctor, congratulations! You’re underway on your journey with ZILXI.

If you haven’t talked to your doctor yet, be sure to ask if ZILXI is right for you. You may have questions before starting your treatment with ZILXI. Speaking with your doctor can provide clarity and comfort.


Questions you may want to ask your doctor:

  • Is ZILXI right for me?
  • When will I see skin improvements?
  • What are the side effects?
  • How long should I continue using ZILXI?
  • Can any lifestyle changes help my rosacea?

Once-a-day application


Step 1 shake

Shake the can well. Place thumb under tab above nozzle and lift up to remove the cap from the ZILXI can.


Step 2 Press

Press the top of the can to dispense a small amount (cherry-sized amount) of ZILXI onto your fingertips.


Step 3 Apply

Apply a thin layer of ZILXI and gently rub onto your entire face. You may need to use additional ZILXI to make sure that your entire face is treated.


Step 4 Wash

Wash your hands after applying ZILXI, which can also stain fabric.

Before applying ZILXI, please remember:

  • When using a new ZILXI can, wait until the can has warmed to room temperature

  • If necessary, wash your face gently with a mild, non-medicated cleanser, rinse with water, and pat your skin dry

  • Apply ZILXI to your face at about the same time each day, at least 1 hour before bedtime. Do not bathe, shower, or swim for at least 1 hour after you apply it.

Yellowing may occur

Due to the yellow tint of ZILXI, some patients may experience a temporary, slight yellow sheen on the skin after applying. This is temporary and may be washed off with soap and water after waiting at least 1 hour.

ZILXI may discolor or stain light-colored fabrics. Applying ZILXI as part of a pre-bedtime routine may help alleviate concerns about fabric staining.


Saving on Zilxi

Pay less with the ZILXI Savings Card

ZILXI Copay Card

With the ZILXI Savings Card, eligible patients can pay as little as $35* 

Get your savings card now

*Additional Eligibility Criteria & Terms: This copay card is not valid for use by patients who are covered by any federal or state-funded healthcare program (including, but not limited to, Medicare [Part D and Medigap], Medicaid, any state pharmaceutical assistance program, TRICARE, VA, or DoD). Offer good only in the U.S., including Puerto Rico. This card is good for use only with a valid ZILXI prescription at the time the prescription is filled by the pharmacist and dispensed to the patient. Void where prohibited by law, taxed, or restricted. This offer cannot be combined with any other promotional offer. Cost may vary based on pharmacy. For full terms and conditions, click here.


Rosacea Resources

Whether you’re looking for community or more information about your disease, here is a list of resources that may be helpful for you:

American Acne & Rosacea Society

American Acne & Rosacea Society

National Rosacea Society

National Rosacea Society

TalkHealth Partnership: Talk Rosacea

TalkHealth Partnership:
Talk Rosacea

Rosacea Research and Development Institute (RRDi)

Rosacea Research and Development Institute (RRDi)


Save on

Pay less with the ZILXI Savings Card*


*Click here for terms and conditions.